Shizune is a fair-skinned woman of average height and slender build with black eyes and hair. Her hair is straight and shoulder-length with bangs that cover her ears and frame her face. Normally, Shizune is seen in a long bluish-black kimono with white trimmings, held closed by a white obi, and open-toed sandals with low heels. Shizune has also been seen wearing the standard Konoha shinobi outfit complete with flak jacket, when deployed on missions which has distinct, extra-long sleeves. She, however, doesn't wear a forehead protector. Shizune also has the tendency to pin her hair up when working; a trait also shared by Sakura.
Shizune is always level-headed, practical and a rational thinker. As a result, she is the one who tends to stress over details, such as Tsunade's tendency to gamble and to think with her heart. She often gets comically worked up over any irrational decision Tsunade makes. Shizune also looks after Tonton, Tsunade's pet pig. She is a very kind and calm person but will immediately rush to Tsunade's aid and in contrast, will become fierce and somewhat ruthless; a testament of her loyalty to Tsunade. At the same time however, she is not timid and is not afraid of objecting to Tsunade's decisions or voicing her opinion as seen when she even alerted the Konoha Council to Tsunade's intention to send Naruto on a mission that Shizune thought would put him in great peril.
She is not the type to tire easily and is very energetic and efficient while acting in her capacity of Hokage's Assistant, often urging Tsunade to finish the paperwork in order to avoid mountains of unsigned documents later on. She is often seen asking Tsunade questions about what to do with the village and the shinobi on missions.
- Medical Ninjutsu: Shizune is noted to be a very talented medical ninja, surpassed only by Tsunade herself. Her prowess set a high standard for Tsunade's other disciples, as the Sannin noted that she had not seen someone with so much skill since Shizune while training Sakura Haruno. Shizune's chakra control is great enough to perform even the most complex medical ninjutsu, leading Tsunade to have the utmost confidence in her. It was due to her control that she was assigned to lead the sealing of the Three-Tails. Shizune demonstrated her great medical knowledge when she lead a group of medical ninja in a complicated procedure that took over three hours while the slightest mistake could be fatal.
- Poison Techniques and Weaponry: Shizune has rarely been seen in battle, but from what has been seen of her skills so far is that she incorporates the use of poison-related techniques during combat. During her battle with Kabuto, Shizune showed the ability to use the Poison Fog technique, creating a thick cloud of toxic gas, capable of being fatal even if only a mere whiff is breathed in, as noted by Kabuto in the Naruto anime.
Keen Intellect: Shizune is quite observant and has a keen intellect.
- Dan Kato (Uncle, deceased)
- Tsunade (Hokage and Mentor)
- Hidden Leaf 11
- Kakashi Hatake